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The Topical Steroid Withdrawal and the Dependence Syndrome: Questionnaire Survey and Case Studies
Krotilová, Zuzana ; Kalina, Kamil (advisor) ; Reichelová, Lenka (referee)
Background: The topical steroid withdrawal (syndrome) or red skin syndrome is a possible topical steroid treatment complication. The bachelor's thesis looks up into patients on topical steroid dependency criteria by particularly atopic dermatitis patients treated with topical steroids. It also deals with the topical steroid withdrawal itself. Aims: The main aim is to get to know whether some difficulties and manifestations of the long-term-topical-steroid treated patients can be defined similarly like the dependency syndrome. Methods: The first method used for the research was quantitative, i.e. an anonymous online questionnaire survey among the trait carriers which included ten DSM-5 dependency criteria questions. In the research sample, there were approximately 900 potencial participants (members of a Facebook group that gathers Czech and Slovak people with RSS). 105 respondents participated. The second method was qualitative - 3 case studies (2 women, 1 man, trait carriers and the sampling was random) of participants whom the medical history were taken from and semi- structured interview were recorded. The interview consisted of some areas of interest and MKN-10 (ICD-10) dependency criteria questions. Results: The degree of fulfillment of the dependency criteria for the online questionnaire...
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Multiple Sclerosis: Corticoid and Biological Therapy, Importance of Pedagogy in Rehabilitation
Rosová, Anna ; Ehler, Edvard (advisor) ; Pavlasová, Lenka (referee)
The submitted thesis deals with the theme of a neurodegenerative autoimmune disease, the sclerosis multiplex. Although this serious disease has become an object of intensive research in recent decades and there is an inexhaustible quantity of literature available, we haven't yet fully identified the causes of this disease as well as we haven't found such kind of effective treatment that would lead to the permanent recovery of patients. I focused my interest on two main spheres: first, the description and comparison of practices in terms of pharmacotherapy giving priority to its benefits to patients, second, the view of another important but not always appreciated part of therapy, physiotherapy or rehabilitation; the main point is studying of processes and actions from the pedagogical point of view.
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Multiple Sclerosis: Corticoid and Biological Therapy, Importance of Pedagogy in Rehabilitation
Rosová, Anna ; Ehler, Edvard (advisor) ; Pavlasová, Lenka (referee)
The submitted thesis deals with the theme of a neurodegenerative autoimmune disease, the sclerosis multiplex. Although this serious disease has become an object of intensive research in recent decades and there is an inexhaustible quantity of literature available, we haven't yet fully identified the causes of this disease as well as we haven't found such kind of effective treatment that would lead to the permanent recovery of patients. I focused my interest on two main spheres: first, the description and comparison of practices in terms of pharmacotherapy giving priority to its benefits to patients, second, the view of another important but not always appreciated part of therapy, physiotherapy or rehabilitation; the main point is studying of processes and actions from the pedagogical point of view.
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Various ways of therapeutic influence on multiple sclerosis
Chalachanová, Katarína ; Posová, Helena (advisor) ; Krulová, Magdaléna (referee)
Multiple sclerosis is an autoimmune demyelinating disease. It hits young adults, but can also break out in middle age. MS causes the permanent physical disability. Among young adults MS occurs as a relaps-remiting form, which later changes into a secondary progressive form. Among older patients, MS occurs from beginning as primary progressive form. The progressive-relapsing is a rare form of MS. The development of the disease is individual and so is the reaction to the treatment. Nowadays, 5 drugs are approved for the treatment of the multiple sclerosis. Most of these drugs reduce the relapse rate, the risk of disability progression and the number and the activity of active lesions. Here we offer the description of currently accessible drugs. The mechanism of immunomodulatory and neuroprotective effect is accented. In the last two sections we offer a short overview of monoclonal antibodies and oral drugs which are under the clinical trials. Keywords: multiple sclerosis, interferon-β, glatiramer acetate, natalizumab, mitoxantrone, fingolimod, corticoids
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